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School Faculty of Science and Technology
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Department Natural Sciences
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Location London
Research activities
Key research areas:
-Antimicrobial resistance-Multi-drug efflux Pumps
-Cell signalling
-Bacterial spores (Clostridium)
-Genotypic and Phenotypic characterisation of community-acquiredMRSA
Thamarai's research focuses on the molecular mechanisms contributing to antimicrobial resistance inGram-negative bacteria, aiming at elucidating the mechanism of how Gram-negative bacteria expel antimicrobial compounds using theResistance-Nodulation & Cell-Division (RND) & Multidrug And ToxinExtrusion Family (MATE) multidrug efflux pumps. His work extensively characterisedthe MtrCDE efflux system from N. gonorrhoeae. With the knowledge andunderstanding of RND transporters, they aim to characterise a MATE transporter from the Gram-negative organism聽Campylobactercoli. His long-term research trajectory will be toinvestigate the interaction of RND and MATE transporters and their role in biofilm formation.
Recent invitedconference talks:
-An international virtualconference on 鈥楶umping Antibiotics鈥� 03/2023
-An international virtualconference on 鈥楤acterial Honeycombs鈥� 03/2022
-An international virtualconference on 鈥楽ustainable Biotechnology鈥� 03/2021
-Delivered an invited talkfor Antibiotics Discovery Accelerator network (ABX), UK conference on鈥楴eglected MATE efflux pumps in Campylobacter鈥� 12/ 2020
-Research seminar talk on鈥楤acterial spores鈥� at the University of Bedfordshire iBEST research institute12/2019聽
-Research seminar on鈥楽tructure and function of tripartite Multi-drug transporters鈥�- Madurai KamarajUniversity 08/ 2017
-Research seminar on 鈥�2Dcrystallization of membrane proteins鈥� Department of Life Sciences, ImperialCollege London, UK, 01/2016
-Conference on 鈥楾hearchitecture of the exosporium basal layer of Clostridial spores鈥� at ImagineLife Symposium, University of Sheffield, UK, 06/2016
-Conference on鈥楥haracterisation of MtrCDE multi-drug efflux pumps from Neisseriagonorrhoeae, BSAC conference held at Birmingham, UK, 11/2013
Current Teaching
Programme Leadership:
Thamarai is the Programme Leader for MScBiomedical Science (Medical Microbiology) and BSc Applied Biomedical Science. He collaborates with external clinical placement providers to support Applied Biomedical Science students' IBMS training Portfolio, such as Health Service Laboratories (HSL), The Doctors Laboratory (TDL), Health Care Laboratories (HCA) and NHS BT. He also chairs the Employer/ IBMS Trainers Liaison group meeting to share feedback on the placement experience.
Modules Lead:
-BMS44806 Infectious Agents and Diagnosis
BMS4806, Human infectious diseases, Prevention and Control.
-BMS3576- Clinical Laboratory Practice (Clinical Placement module)
Curriculum Development:
Developed a number ofmodules and teaching materials for microbiology-related modules for UG and MScprogrammes.聽
Actively involved in a number of Programme revalidation and re-accreditation events at various HEIs.